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Description for Protein TPP2

tripeptidyl peptidase II
No Interacting Proteins
Icon Book Platelet Evidence (proteome studies/others : 5/0)
(membrane: 1; microparticles: 1; platelet: 2; secretome: 2)
Summary:
This gene encodes a mammalian peptidase that, at neutral pH, removes tripeptides from the N terminus of longer peptides. The protein has a specialized function that is essential for some MHC class I antigen presentation. The protein is a high molecular mass serine exopeptidase; the amino acid sequence surrounding the serine residue at the active site is similar to the peptidases of the subtilisin class rather than the trypsin class. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.4.14.10
    KEGG - Orthology:
    K01280
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Tripeptidyl aminopeptidase; TPP-II
    Approved Symbol:
    TPP2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 5
    Human (de-) phosphorylation sites: 5; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01834 Entrez Gene ID: 7174 OMIM ID: 190470 Swissprot Accession: P29144;