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Description for Protein TPO

thyroid peroxidase
2 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a membrane-bound glycoprotein. The encoded protein acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Multiple transcript variants encoding distinct isoforms have been identified for this gene. Additional splice variants have been described but their biological natures have not been determined. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • SUSHI: Sushi domain (SCR repeat)
  • EGFCA: Calcium-binding EGF-like domain
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    1.11.1.8
    KEGG - Orthology:
    K00431
    KEGG - Pathway(s):
    hsa00350; hsa01100; hsa04060; hsa04630; hsa04640; hsa05320
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    EC 1.11.1.8; MSA; TPX; Thyroperoxidase; Thyroid microsomal antigen; Thyroid peroxidase isoform a; Thyroid peroxidase isoform c; Thyroid peroxidase isoform d; Thyroid peroxidase isoform b; Thyroid peroxidase isoform e
    Approved Symbol:
    TPO
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Carbimazole(db);
  • Dextrothyroxine(db);
  • Methimazole(db);
  • Propylthiouracil(db)

    Associated Genetic Diseases:

  • Thyroid hormonogenesis, genetic defect in, 2A(Pd);
  • Total iodide organification defect(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 5 : 1
  • Isoform 4 : 1
  • Isoform 3 : 1
  • Isoform 2 : 1
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 06000 Entrez Gene ID: 7173 OMIM ID: 606765 Swissprot Accession: P07202; Q6P534; Q502Y3;