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Description for Protein TPM2

tropomyosin 2 (beta)
10 total interacting proteins; 8 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 9/0)
(membrane: 1; microparticles: 1; platelet: 8; secretome: 1)
Summary:
This gene encodes beta-tropomyosin, a member of the actin filament binding protein family, and mainly expressed in slow, type 1 muscle fibers. Mutations in this gene can alter the expression of other sarcomeric tropomyosin proteins, and cause cap disease, nemaline myopathy and distal arthrogryposis syndromes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
None Available
KEGG - Orthology:
K10374
KEGG - Pathway(s):
hsa04260; hsa05410; hsa05414
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
Tropomyosin 2 (beta) isoform 2; Tropomyosin beta chain; Beta tropomyosin; TMSB; Tropomyosin 2 (beta) isoform 1
Approved Symbol:
TPM2
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 7
Human (de-) phosphorylation sites: 7; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

None Available

Associated Genetic Diseases:

  • Arthrogryposis multiplex congenita, distal, type 1(Pd);
  • Nemaline myopathy 4(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 11768 Entrez Gene ID: 7169 OMIM ID: 190990 Swissprot Accession: P07951;