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Description for Protein TPM1

tropomyosin 1 (alpha)
14 total interacting proteins; 8 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 10/1)
(membrane: 1; microparticles: 1; platelet: 12; secretome: 7)
Summary:
This gene is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The encoded protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction. In smooth muscle and non-muscle cells, alternatively spliced transcript variants encoding a range of isoforms have been described. Mutations in this gene are associated with type 3 familial hypertrophic cardiomyopathy. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K10373
    KEGG - Pathway(s):
    hsa04260; hsa05410; hsa05414
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    TPM1-kappa; Sarcomeric tropomyosin kappa; Tropomyosin skeletal muscle alpha; Alpha tropomyosin; Tropomyosin 1 alpha chain isoform 5; Tropomyosin 1 alpha chain isoform 3; TM2 fibroblast isoform; Tropomyosin 1 alpha chain isoform 1; Fast skeletal muscle isoform; Tropomyosin 1 alpha chain isoform 4; TM3 fibroblast isoform; Tropomyosin 1 alpha chain isoform 2; Smooth muscle isoform; Tropomyosin 1 alpha chain isoform 6; TMBr3 brain isoform; Tropomyosin 1 alpha chain isoform 7; Tropomyosin 1; Tropomyosin 1 alpha; HTM-alpha; TMSA
    Approved Symbol:
    TPM1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 13
    Human (de-) phosphorylation sites: 13; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Cardiomyopathy, familial hypertrophic, 3(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 7 : 0
  • Isoform 6 : 0
  • Isoform 5 : 0
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01839 Entrez Gene ID: 7168 OMIM ID: 191010 Swissprot Accession: O15513; P09493; Q9Y427;