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Description for Protein TPI1

triosephosphate isomerase 1
8 total interacting proteins; 4 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 11/1)
(membrane: 1; microparticles: 1; platelet: 9; secretome: 2)
Summary:
This gene encodes an enzyme, consisting of two identical proteins, which catalyzes the isomerization of glyceraldehydes 3-phosphate (G3P) and dihydroxy-acetone phosphate (DHAP) in glycolysis and gluconeogenesis. Mutations in this gene are associated with triosephosphate isomerase deficiency. Pseudogenes have been identified on chromosomes 1, 4, 6 and 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
5.3.1.1
KEGG - Orthology:
K01803
KEGG - Pathway(s):
hsa00010; hsa00051; hsa00562; hsa01100
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
TPI; Triosephosphate isomerase; TIM; D glyceraldehyde 3 phosphate keto isomerase
Approved Symbol:
TPI1
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 12
Human (de-) phosphorylation sites: 12; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • 1,3-Dihydroxyacetonephosphate(db);
  • 1,4-Dithiothreitol(db);
  • 2-Carboxyethylphosphonic Acid(db);
  • 2-Methyl-2-Propanol(db);
  • 2-Phosphoglycolic Acid(db);
  • 3-(2-Benzothiazolylthio)-1-Propanesulfonic Acid(db);
  • 3-(BUTYLSULPHONYL)-PROPANOIC ACID(db);
  • 3-Phosphoglyceric Acid(db);
  • Acetate Ion(db);
  • Dimethyl sulfoxide(db);
  • Fluorotryptophane(db);
  • N-Hydroxy-4-Phosphono-Butanamide(db);
  • Phosphoglycolohydroxamic Acid(db);
  • [2(Formyl-Hydroxy-Amino)-Ethyl]-Phosphonic Acid(db)

    Associated Genetic Diseases:

  • Triosephosphate isomerase deficiency(Pd);
  • Triosephosphate isomerase manchester(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01833 Entrez Gene ID: 7167 OMIM ID: 190450 Swissprot Accession: P60174; Q53HE2;