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Description for Protein TPH1

tryptophan hydroxylase 1
3 total interacting proteins; 3 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a member of the aromatic amino acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene have been associated with an elevated risk for a variety of diseases and disorders, including schizophrenia, somatic anxiety, anger-related traits, bipolar disorder, suicidal behavior, addictions, and others. (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
1.14.16.4
KEGG - Orthology:
K00502
KEGG - Pathway(s):
hsa00380; hsa01100
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
Tryptophan 5-hydroxylase 1; TPH; Tryptophan 5-monooxygenase 1; Tryptophan 5-monooxygenase; TPRH; Tryptophan 5-hydroxylase
Approved Symbol:
TPH1
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 3
Human (de-) phosphorylation sites: 3; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • 7,8-Dihydro-L-Biopterin(db);
  • L-Tryptophan(db);
  • Tetrahydrobiopterin(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01846 Entrez Gene ID: 7166 OMIM ID: 191060 Swissprot Accession: P17752;