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Description for Protein C1S

complement component 1, s subcomponent
4 total interacting proteins; 3 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(secretome: 1)
Summary:
This gene encodes a serine protease, which is a major constituent of the human complement subcomponent C1. C1s associates with two other complement components C1r and C1q in order to yield the first component of the serum complement system. Defects in this gene are the cause of selective C1s deficiency. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • EGFCA: Calcium-binding EGF-like domain
  • CUB: Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein.
  • SUSHI: Sushi domain (SCR repeat)
  • TRYPSIN: Trypsin-like serine protease
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.4.21.42
    KEGG - Orthology:
    K01331
    KEGG - Pathway(s):
    hsa04610; hsa05322
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    C1 esterase; Complement C1s subcomponent
    Approved Symbol:
    C1S
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • 2-(2-Hydroxy-1,1-Dihydroxymethyl-Ethylamino)-Ethanesulfonic Acid(db);
  • Abciximab(db);
  • Adalimumab(db);
  • Basiliximab(db);
  • Cetuximab(db);
  • Etanercept(db);
  • Fucose(db);
  • Gemtuzumab ozogamicin(db);
  • Ibritumomab(db);
  • Muromonab(db);
  • Rituximab(db);
  • Trastuzumab(db)

    Associated Genetic Diseases:

  • C1s deficiency(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00397 Entrez Gene ID: 716 OMIM ID: 120580 Swissprot Accession: P09871;