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Description for Protein TP53

tumor protein p53
388 total interacting proteins; 150 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes tumor protein p53, which responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and hence cause the loss of tumor suppressor activity. Alterations of this gene occur not only as somatic mutations in human malignancies, but also as germline mutations in some cancer-prone families with Li-Fraumeni syndrome. Multiple p53 variants due to alternative promoters and multiple alternative splicing have been found. These variants encode distinct isoforms, which can regulate p53 transcriptional activity. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
None Available
KEGG - Orthology:
K04451
KEGG - Pathway(s):
hsa04010; hsa04110; hsa04115; hsa04210; hsa04310; hsa04722; hsa05014; hsa05016; hsa05200; hsa05210; hsa05212; hsa05213; hsa05214; hsa05215; hsa05216; hsa05217; hsa05218; hsa05219; hsa05220; hsa05222; hsa05223
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
Transformation related protein 53; TRP53
Approved Symbol:
TP53
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 39
Human (de-) phosphorylation sites: 39; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • 1-(9-ethyl-9H-carbazol-3-yl)-N-methylmethanamine(db)

    Associated Genetic Diseases:

  • Adrenocortical carcinoma, pediatric(Pd);
  • Breast cancer(Pd);
  • Choroid plexus papilloma(Pd);
  • Colon tumors, concurrent multiple primary(Pd);
  • Hepatoblastoma(Pd);
  • Hepatocellular carcinoma(Pd);
  • Histiocytoma, malignant fibrous(Pd);
  • Li-Fraumeni syndrome(Pd);
  • Li-Fraumeni syndrome 1(Pd);
  • Multiple malignancy syndrome(Pd);
  • Nasopharyngeal carcinoma(Pd);
  • Osteosarcoma(Pd);
  • Pancreatic cancer(Pd);
  • Tp53 polymorphism(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 7 : 0
  • Isoform 6 : 0
  • Isoform 5 : 0
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01859 Entrez Gene ID: 7157 OMIM ID: 191170 Swissprot Accession: Q53GA5; P04637; Q3LRW5;