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Description for Protein TOP3A

topoisomerase (DNA) III alpha
3 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus reducing the number of supercoils and altering the topology of DNA. This enzyme forms a complex with BLM which functions in the regulation of recombination in somatic cells. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • ZnF_C2HC: zinc finger
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    5.99.1.2
    KEGG - Orthology:
    K03165
    KEGG - Pathway(s):
    hsa03440
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Topoisomerase DNA III; TOP3; Topo III alpha; EC 5.99.1.2
    Approved Symbol:
    TOP3A
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 3
    Human (de-) phosphorylation sites: 3; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03145 Entrez Gene ID: 7156 OMIM ID: 601243 Swissprot Accession: Q13472;