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Description for Protein TOP2A

topoisomerase (DNA) II alpha 170kDa
32 total interacting proteins; 16 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    5.99.1.3
    KEGG - Orthology:
    K03164
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    DNA topoisomerase II; TOP2; EC 5.99.1.3
    Approved Symbol:
    TOP2A
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 54
    Human (de-) phosphorylation sites: 54; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Amsacrine(db);
  • Ciprofloxacin(db);
  • Daunorubicin(db);
  • Dexrazoxane(db);
  • Doxorubicin(db);
  • Enoxacin(db);
  • Epirubicin(db);
  • Etoposide(db);
  • Fleroxacin(db);
  • Genistein(db);
  • Idarubicin(db);
  • Levofloxacin(db);
  • Lomefloxacin(db);
  • Lucanthone(db);
  • Mitoxantrone(db);
  • Moxifloxacin(db);
  • Norfloxacin(db);
  • Ofloxacin(db);
  • Pefloxacin(db);
  • Podofilox(db);
  • Sparfloxacin(db);
  • Teniposide(db);
  • Trovafloxacin(db);
  • Valrubicin(db)

    Associated Genetic Diseases:

  • Dna topoisomerase II, resistance to inhibition of, by amsacrine(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00536 Entrez Gene ID: 7153 OMIM ID: 126430 Swissprot Accession: P11388;