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Description for Protein C1R

complement component 1, r subcomponent
6 total interacting proteins; 5 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
(PubMed Links)
Domains and Motifs:
  • EGFCA: Calcium-binding EGF-like domain
  • CUB: Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein.
  • SUSHI: Sushi domain (SCR repeat)
  • TRYPSIN: Trypsin-like serine protease
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.4.21.41
    KEGG - Orthology:
    K01330
    KEGG - Pathway(s):
    hsa04610; hsa05322
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    C1r; Complement component C1r
    Approved Symbol:
    C1R
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 3
    Human (de-) phosphorylation sites: 3; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Abciximab(db);
  • Adalimumab(db);
  • Alefacept(db);
  • Alemtuzumab(db);
  • Alpha-D-Mannose(db);
  • Basiliximab(db);
  • Bevacizumab(db);
  • Cetuximab(db);
  • Daclizumab(db);
  • Efalizumab(db);
  • Etanercept(db);
  • Fucose(db);
  • Gemtuzumab ozogamicin(db);
  • Ibritumomab(db);
  • Muromonab(db);
  • Natalizumab(db);
  • Palivizumab(db);
  • Rituximab(db);
  • Tositumomab(db);
  • Trastuzumab(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01954 Entrez Gene ID: 715 OMIM ID: 216950 Swissprot Accession: P00736;