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Description for Protein C1QC

complement component 1, q subcomponent, C chain
4 total interacting proteins; 4 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(secretome: 1)
Summary:
This gene encodes a major constituent of the human complement subcomponent C1q. C1q associates with C1r and C1s in order to yield the first component of the serum complement system. A deficiency in C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N-terminus, and a C-terminal globular region. The A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1. This gene encodes the C-chain polypeptide of human complement subcomponent C1q. Alternatively spliced transcript variants that encode the same protein have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • C1Q: Complement component C1q domain.
  • COLL: Collagen triple helix repeat (20 copies)
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K03988
    KEGG - Pathway(s):
    hsa04610; hsa05020; hsa05142; hsa05322
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Complement component 1, q subcomponent, gamma polypeptide; C1QC
    Approved Symbol:
    C1QC
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Abciximab(db);
  • Adalimumab(db);
  • Alefacept(db);
  • Alemtuzumab(db);
  • Basiliximab(db);
  • Bevacizumab(db);
  • Cetuximab(db);
  • Daclizumab(db);
  • Efalizumab(db);
  • Etanercept(db);
  • Gemtuzumab ozogamicin(db);
  • Ibritumomab(db);
  • Muromonab(db);
  • Natalizumab(db);
  • Palivizumab(db);
  • Rituximab(db);
  • Tositumomab(db);
  • Trastuzumab(db)

    Associated Genetic Diseases:

  • C1q deficiency, type C(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00395 Entrez Gene ID: 714 OMIM ID: 120575 Swissprot Accession: P02747;