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Description for Protein TNNC1

troponin C type 1 (slow)
8 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(platelet: 1)
Summary:
Troponin is a central regulatory protein of striated muscle contraction, and together with tropomyosin, is located on the actin filament. Troponin consists of 3 subunits: TnI, which is the inhibitor of actomyosin ATPase; TnT, which contains the binding site for tropomyosin; and TnC, the protein encoded by this gene. The binding of calcium to TnC abolishes the inhibitory action of TnI, thus allowing the interaction of actin with myosin, the hydrolysis of ATP, and the generation of tension. Mutations in this gene are associated with cardiomyopathy dilated type 1Z. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • EF: EF-hand, calcium binding motif
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K05865
    KEGG - Pathway(s):
    hsa04020; hsa04260; hsa05410; hsa05414
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Troponin C1, slow; Cardiac troponin C; Troponin C, slow skeletal and cardiac muscles; Troponin C, slow twitch skeletal muscle; Troponin C, cardiac; TNNC; TNC
    Approved Symbol:
    TNNC1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 1
    Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • 5-[1-(3,4-Dimethoxy-Benzoyl)-1,2,3,4-Tetrahydro-Quinolin-6-Yl]-6-Methyl-3,6-Dihydro-[1,3,4]Thiadiazin-2-One(db);
  • Bepridil(db);
  • Calcium(db);
  • Dihydroxyaluminium(db);
  • Felodipine(db);
  • Levosimendan(db);
  • N-(6-Aminohexyl)-5-Chloro-1-Naphthalenesulfonamide(db);
  • Trifluoperazine(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 08930 Entrez Gene ID: 7134 OMIM ID: 191040 Swissprot Accession: P63316; Q6FH91;