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Description for Protein TNFRSF1A

tumor necrosis factor receptor superfamily, member 1A
64 total interacting proteins; 35 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is one of the major receptors for the tumor necrosis factor-alpha. This receptor can activate NF-kappaB, mediate apoptosis, and function as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of this receptor were found to be associated with the autosomal dominant periodic fever syndrome. The impaired receptor clearance is thought to be a mechanism of the disease. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • TNFR: Tumor necrosis factor receptor / nerve growth factor receptor repeats.
  • TM: Transmembrane domain
  • DEATH: DEATH domain, found in proteins involved in cell death (apoptosis).
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K03158
    KEGG - Pathway(s):
    hsa04010; hsa04060; hsa04210; hsa04920; hsa05010; hsa05014; hsa05142
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    TNFR1, alpha; TNFR1; Tumor necrosis factor receptor superfamily, member 1A; p55 TNFR; TNF-R55; TNFR 55-Kd; TNFR 60-Kd
    Approved Symbol:
    TNFRSF1A
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 2
    Human (de-) phosphorylation sites: 2; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • 6-[3-(4-Morpholinyl)Propyl]-2-(3-Nitrophenyl)-5-Thioxo-5,6,-Dihydro-7h-Thienol[2',3':4,5]Pyrrolo[1,2-C]Imidazol-7-One(db)

    Associated Genetic Diseases:

  • Periodic fever, familial, autosomal dominant(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 2
    • Additional Identifiers:

    HPRD: 01861 Entrez Gene ID: 7132 OMIM ID: 191190 Swissprot Accession: P19438;