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Description for Protein TNFAIP3

tumor necrosis factor, alpha-induced protein 3
37 total interacting proteins; 20 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene was identified as a gene whose expression is rapidly induced by the tumor necrosis factor (TNF). The protein encoded by this gene is a zinc finger protein, and has been shown to inhibit NF-kappa B activation as well as TNF-mediated apoptosis. Knockout studies of a similar gene in mice suggested that this gene is critical for limiting inflammation by terminating TNF-induced NF-kappa B responses. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
3.-.-.-
KEGG - Orthology:
K11859
KEGG - Pathway(s):
hsa04621
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
Tumor necrosis factor alpha induced protein 3; A20; Tumor necrosis factor inducible protein A20
Approved Symbol:
TNFAIP3
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 13
Human (de-) phosphorylation sites: 13; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

None Available

Associated Genetic Diseases:

None Available
Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01857 Entrez Gene ID: 7128 OMIM ID: 191163 Swissprot Accession: P21580;