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Description for Protein TNF

tumor necrosis factor
19 total interacting proteins; 8 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(undefined: 1)
Summary:
This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
  • TNF: Tumour necrosis factor family.
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K03156
    KEGG - Pathway(s):
    hsa04010; hsa04060; hsa04210; hsa04350; hsa04612; hsa04620; hsa04621; hsa04622; hsa04640; hsa04650; hsa04660; hsa04664; hsa04920; hsa04930; hsa04940; hsa05010; hsa05014; hsa05140; hsa05142; hsa05144; hsa05310; hsa05322; hsa05330; hsa05332; hsa05410; hsa05414
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Tumor necrosis factor; Tumor necrosis factor, alpha; TNFA; Cachectin
    Approved Symbol:
    TNF
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 1
    Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Adalimumab(db);
  • Amrinone(db);
  • Chloroquine(db);
  • Clenbuterol(db);
  • Etanercept(db);
  • Glucosamine(db);
  • Infliximab(db);
  • Isopropyl Alcohol(db);
  • Pranlukast(db);
  • Thalidomide(db)

    Associated Genetic Diseases:

  • Alzheimer disease, protection against(Pd);
  • Malaria, cerebral, susceptibility to(Pd);
  • Septic shock, susceptibility to(Pd);
  • TNF receptor binding, altered(Pd);
  • Vascular dementia, susceptibility to(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 01855 Entrez Gene ID: 7124 OMIM ID: 191160 Swissprot Accession: P01375; Q5STB3; C1K3N5;