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Description for Protein C1QA

complement component 1, q subcomponent, A chain
18 total interacting proteins; 9 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(platelet: 1)
Summary:
This gene encodes a major constituent of the human complement subcomponent C1q. C1q associates with C1r and C1s in order to yield the first component of the serum complement system. Deficiency of C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N terminus and a C-terminal globular region. The A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1. This gene encodes the A-chain polypeptide of human complement subcomponent C1q. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • C1Q: Complement component C1q domain.
  • COLL: Collagen triple helix repeat (20 copies)
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K03986
    KEGG - Pathway(s):
    hsa04610; hsa05020; hsa05142; hsa05322
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Complement component 1, q subcomponent, alpha polypeptide; Serum C1q
    Approved Symbol:
    C1QA
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Abciximab(db);
  • Adalimumab(db);
  • Alefacept(db);
  • Alemtuzumab(db);
  • Basiliximab(db);
  • Bevacizumab(db);
  • Cetuximab(db);
  • Daclizumab(db);
  • Efalizumab(db);
  • Etanercept(db);
  • Gemtuzumab ozogamicin(db);
  • Ibritumomab(db);
  • Muromonab(db);
  • Natalizumab(db);
  • Palivizumab(db);
  • Rituximab(db);
  • Tositumomab(db);
  • Trastuzumab(db)

    Associated Genetic Diseases:

  • C1q deficiency, type A(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00393 Entrez Gene ID: 712 OMIM ID: 120550 Swissprot Accession: P02745;