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Description for Protein TLR2

toll-like receptor 2
20 total interacting proteins; 8 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(undefined: 1)
Summary:
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via stimulation of NF-kappaB. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • LRR: Leucine-rich repeats, outliers
  • TM: Transmembrane domain
  • TIR: Toll - interleukin 1 - resistance
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K10159
    KEGG - Pathway(s):
    hsa04620; hsa05140; hsa05142; hsa05144
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    TIL4; Toll/interleukin 1 receptor like protein 4
    Approved Symbol:
    TLR2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • OspA lipoprotein(db);
  • S-(Dimethylarsenic)Cysteine(db)

    Associated Genetic Diseases:

  • Colorectal cancer, susceptibility to(Pd);
  • Leprosy, susceptibility to(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 04323 Entrez Gene ID: 7097 OMIM ID: 603028 Swissprot Accession: O60603; B3KWR9; D1CS45;