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Description for Protein TLN1

talin 1
21 total interacting proteins; 18 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 14/2)
(alpha granules: 1; cAMP/cGMP binding: 1; membrane: 2; microparticles: 1; phosphoproteome: 1; platelet: 9; secretome: 1; undefined: 1)
Summary:
This gene encodes a cytoskeletal protein that is concentrated in areas of cell-substratum and cell-cell contacts. The encoded protein plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. It codistributes with integrins in the cell surface membrane in order to assist in the attachment of adherent cells to extracellular matrices and of lymphocytes to other cells. The N-terminus of this protein contains elements for localization to cell-extracellular matrix junctions. The C-terminus contains binding sites for proteins such as beta-1-integrin, actin, and vinculin. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • CC: Coiled Coil
  • B41: Band 4.1 homologues
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K06271
    KEGG - Pathway(s):
    hsa04510
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    TLN; ILWEQ; KIAA1027; Talin 1
    Approved Symbol:
    TLN1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 23
    Human (de-) phosphorylation sites: 23; Platelet phosphorylation sites: 1
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01726 Entrez Gene ID: 7094 OMIM ID: 186745 Swissprot Accession: Q9Y490;