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Description for Protein TJP1

tight junction protein 1 (zona occludens 1)
42 total interacting proteins; 19 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(platelet: 1)
Summary:
This gene encodes a protein located on a cytoplasmic membrane surface of intercellular tight junctions. The encoded protein may be involved in signal transduction at cell-cell junctions. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • ZU5: Domain present in ZO-1 and Unc5-like netrin receptors
  • PDZ: Domain present in PSD-95, Dlg, and ZO-1/2.
  • SH3: Src homology 3 domains
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K05701
    KEGG - Pathway(s):
    hsa04520; hsa04530; hsa04540; hsa05110; hsa05120
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Zona occludens 1; Zonula occludens 1; ZO1; Tight junction protein ZO-1; Tight junction protein 1 isoform b; Tight junction protein 1 isoform a
    Approved Symbol:
    TJP1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 135
    Human (de-) phosphorylation sites: 135; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03002 Entrez Gene ID: 7082 OMIM ID: 601009 Swissprot Accession: Q6MZU1; Q07157;