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Description for Protein THRA

thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)
51 total interacting proteins; 18 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(platelet: 1)
Summary:
The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • CC: Coiled Coil
  • HOLI: Ligand binding domain of hormone receptors
  • ZnF_C4: c4 zinc finger in nuclear hormone receptors
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K05547
    KEGG - Pathway(s):
    hsa04080
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Triiodothyronine receptor; TR alpha 1; c-ERBA alpha 2; C-erbA alpha; c-erbA1; EAR-7; EAR7; THRA3; THRA1; ERBA related 7; EAR-7.1/EAR-7.2; Thyroid hormone receptor alpha 1; Thyroid hormone receptor alpha 2; Thyroid hormone receptor alpha 3; ERBA; NR1A1; Thyroid hormone recptor, central nervous system form; ERBA alpha; Oncogene ERBA; ERBA-related 7; T3 receptor; AR7; EAR-7.1; EAR-7.2; ERB-T-1; ERBA1; Erythroblastic leukemia viraloncogene homolog; THRA2; MGC000261; Thyroid hormone receptor, alpha isoform 2; Thyroid hormone receptor, alpha isoform 1
    Approved Symbol:
    THRA
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • 3,5-Dichloro-4-[(4-Hydroxy-3-Isopropylphenoxy)Phenylacetic Acid(db);
  • Dextrothyroxine(db);
  • Levothyroxine(db);
  • Liothyronine(db);
  • Liotrix(db);
  • {4-[4-hydroxy-3-(1-methylethyl)benzyl]-3,5-dimethylphenoxy}acetic acid(db)

    Associated Genetic Diseases:

  • Pituitary adenoma, nonfunctioning(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 07185 Entrez Gene ID: 7067 OMIM ID: 190120 Swissprot Accession: P10827; Q6FH41;