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Description for Protein TSPO

translocator protein (18kDa)
2 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(membrane: 1)
Summary:
Present mainly in the mitochondrial compartment of peripheral tissues, the protein encoded by this gene interacts with some benzodiazepines and has different affinities than its endogenous counterpart. The protein is a key factor in the flow of cholesterol into mitochondria to permit the initiation of steroid hormone synthesis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K05770
    KEGG - Pathway(s):
    hsa04080
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    MBR; PBR; PBRS; Peripheral type benzodiazepine receptor; PKBS; Mitochondrial benzodiazepine receptor; PBS; Peripheral benzodiazapine receptor isoform PBR-S; Peripheral benzodiazapine receptor isoform PBR
    Approved Symbol:
    TSPO
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 1
    Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Alprazolam(db);
  • Chlormezanone(db);
  • Clonazepam(db);
  • Clorazepate(db);
  • Diazepam(db);
  • Eszopiclone(db);
  • Flunitrazepam(db);
  • Ketazolam(db);
  • Lorazepam(db);
  • Temazepam(db);
  • Triazolam(db);
  • Zaleplon(db);
  • Zopiclone(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 5
    • Additional Identifiers:

    HPRD: 15913 Entrez Gene ID: 706 OMIM ID: 109610 Swissprot Accession: B1AH88; P30536;