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Description for Protein THBS2

thrombospondin 2
4 total interacting proteins; 3 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 3/0)
(alpha granules: 1; platelet: 2)
Summary:
The protein encoded by this gene belongs to the thrombospondin family. It is a disulfide-linked homotrimeric glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein has been shown to function as a potent inhibitor of tumor growth and angiogenesis. Studies of the mouse counterpart suggest that this protein may modulate the cell surface properties of mesenchymal cells and be involved in cell adhesion and migration. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TSPN: Thrombospondin N-terminal -like domains.
  • VWC: von Willebrand factor (vWF) type C domain
  • TSP1: Thrombospondin type 1 repeats
  • EGF: Epidermal growth factor-like domain.
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04659
    KEGG - Pathway(s):
    hsa04350; hsa04510; hsa04512; hsa05144
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    TSP2
    Approved Symbol:
    THBS2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01766 Entrez Gene ID: 7058 OMIM ID: 188061 Swissprot Accession: P35442; Q6MZL6;