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Description for Protein THBS1

thrombospondin 1
39 total interacting proteins; 26 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 14/3)
(alpha granules: 2; cAMP/cGMP binding: 1; membrane: 2; microparticles: 1; platelet: 9; secretome: 2; undefined: 2)
Summary:
The protein encoded by this gene is a subunit of a disulfide-linked homotrimeric protein. This protein is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1. This protein has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • TSPN: Thrombospondin N-terminal -like domains.
  • CC: Coiled Coil
  • VWC: von Willebrand factor (vWF) type C domain
  • TSP1: Thrombospondin type 1 repeats
  • EGFCA: Calcium-binding EGF-like domain
  • EGF: Epidermal growth factor-like domain.
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04659
    KEGG - Pathway(s):
    hsa04115; hsa04350; hsa04510; hsa04512; hsa05144; hsa05219
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    TSP1; TSP
    Approved Symbol:
    THBS1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Fucose(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01765 Entrez Gene ID: 7057 OMIM ID: 188060 Swissprot Accession: P07996;