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Description for Protein THBD

thrombomodulin
4 total interacting proteins; 3 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this intronless gene is an endothelial-specific type I membrane receptor that binds thrombin. This binding results in the activation of protein C, which degrades clotting factors Va and VIIIa and reduces the amount of thrombin generated. Mutations in this gene are a cause of thromboembolic disease, also known as inherited thrombophilia. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • EGF: Epidermal growth factor-like domain.
  • LECTIN_C: C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
  • EGFL: EGF domain, unclasssified subfamily
  • EGFCA: Calcium-binding EGF-like domain
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K03907
    KEGG - Pathway(s):
    hsa04610
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    THRM; Fetomodulin; CD141
    Approved Symbol:
    THBD
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Drotrecogin alfa(db)

    Associated Genetic Diseases:

  • Myocardial infarction, susceptibility to(Pd);
  • Thrombophilia due to thrombomodulin defect(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 01764 Entrez Gene ID: 7056 OMIM ID: 188040 Swissprot Accession: P07204;