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Description for Protein TGM3

transglutaminase 3 (E polypeptide, protein-glutamine-gamma-glutamyltransferase)
4 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(secretome: 1)
Summary:
Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene consists of two polypeptide chains activated from a single precursor protein by proteolysis. The encoded protein is involved the later stages of cell envelope formation in the epidermis and hair follicle. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TGC: Transglutaminase/protease-like homologues
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.3.2.13
    KEGG - Orthology:
    K05620
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Transglutaminase E; TGase E; TGE
    Approved Symbol:
    TGM3
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 4
    Human (de-) phosphorylation sites: 4; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • 5'-Guanosine-Diphosphate-Monothiophosphate(db);
  • B-2-Octylglucoside(db);
  • Guanosine-5'-Diphosphate(db);
  • Guanosine-5'-Monophosphate(db);
  • L-Glutamine(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02584 Entrez Gene ID: 7053 OMIM ID: 600238 Swissprot Accession: Q08188;