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Description for Protein TGFB3

transforming growth factor, beta 3
10 total interacting proteins; 6 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a member of the TGF-beta family of proteins. The encoded protein is secreted and is involved in embryogenesis and cell differentiation. Defects in this gene are a cause of familial arrhythmogenic right ventricular dysplasia 1. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • TGFB: Transforming growth factor-beta (TGF-beta) family
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K13377
    KEGG - Pathway(s):
    hsa04010; hsa04060; hsa04110; hsa04144; hsa04350; hsa05140; hsa05142; hsa05144; hsa05200; hsa05210; hsa05211; hsa05212; hsa05220; hsa05410; hsa05414
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Transforming growth factor, beta 3
    Approved Symbol:
    TGFB3
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 1
    Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • 1,4-Diethylene Dioxide(db)

    Associated Genetic Diseases:

  • Arrhythmogenic right ventricular dysplasia 1(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 01829 Entrez Gene ID: 7043 OMIM ID: 190230 Swissprot Accession: P10600; B3KVH9; A5YM40;