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Description for Protein TGFB1

transforming growth factor, beta 1
40 total interacting proteins; 23 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 8/2)
(alpha granules: 1; membrane: 1; microparticles: 1; platelet: 5; secretome: 1; undefined: 1)
Summary:
This gene encodes a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types. Many cells have TGFB receptors, and the protein positively and negatively regulates many other growth factors. The secreted protein is cleaved into a latency-associated peptide (LAP) and a mature TGFB1 peptide, and is found in either a latent form composed of a TGFB1 homodimer, a LAP homodimer, and a latent TGFB1-binding protein, or in an active form composed of a TGFB1 homodimer. The mature peptide may also form heterodimers with other TGFB family members. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease. (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • TGFB: Transforming growth factor-beta (TGF-beta) family
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K13375
    KEGG - Pathway(s):
    hsa04010; hsa04060; hsa04110; hsa04144; hsa04350; hsa04672; hsa05140; hsa05142; hsa05144; hsa05200; hsa05210; hsa05211; hsa05212; hsa05220; hsa05410; hsa05414
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    TGF beta; TGFB; Transforming growth factor beta 1
    Approved Symbol:
    TGFB1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Hyaluronidase(db)

    Associated Genetic Diseases:

  • Camurati-Engelmann disease(Pd);
  • Cystic fibrosis lung disease, modifier of(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01821 Entrez Gene ID: 7040 OMIM ID: 190180 Swissprot Accession: P01137;