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Description for Protein TF

transferrin
16 total interacting proteins; 7 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 10/0)
(alpha granules: 1; membrane: 1; microparticles: 1; platelet: 5; secretome: 3)
Summary:
This gene encodes a glycoprotein with an approximate molecular weight of 76.5 kDa. It is thought to have been created as a result of an ancient gene duplication event that led to generation of homologous C and N-terminal domains each of which binds one ion of ferric iron. The function of this protein is to transport iron from the intestine, reticuloendothelial system, and liver parenchymal cells to all proliferating cells in the body. This protein may also have a physiologic role as granulocyte/pollen-binding protein (GPBP) involved in the removal of certain organic matter and allergens from serum. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • TR_FER: Transferrin
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    None Available
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Beta 1 metal binding globulin; Siderophilin
    Approved Symbol:
    TF
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 4
    Human (de-) phosphorylation sites: 4; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Aluminium(db);
  • Fucose(db);
  • Oxalate Ion(db)

    Associated Genetic Diseases:

  • Atransferrinemia(Pd);
  • Iron deficiency anemia, susceptibility to(Pd);
  • Transferrin variant B2(Pd);
  • Transferrin variant BV(Pd);
  • Transferrin variant C1/C2(Pd);
  • Transferrin variant CHI(Pd);
  • Transferrin variant D1(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01811 Entrez Gene ID: 7018 OMIM ID: 190000 Swissprot Accession: A0PJA6; P02787; Q06AH7;