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Description for Protein TERF1

telomeric repeat binding factor (NIMA-interacting) 1
37 total interacting proteins; 17 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(platelet: 1)
Summary:
This gene encodes a telomere specific protein which is a component of the telomere nucleoprotein complex. This protein is present at telomeres throughout the cell cycle and functions as an inhibitor of telomerase, acting in cis to limit the elongation of individual chromosome ends. The protein structure contains a C-terminal Myb motif, a dimerization domain near its N-terminus and an acidic N-terminus. Two transcripts of this gene are alternatively spliced products. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • NLS: Nuclear localization signal
  • SANT: SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K11110
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    TTAGGG repeat binding factor 1; NIMA interacting protein 2; Telomeric protein Pin2/TRF1; TRF1; TRF; PIN2; t-TRF1; TRBF1; hTRF1-AS; Telomeric repeat binding protein 1; Telomeric repeat binding factor 1 isoform 2; Telomeric repeat binding factor 1 isoform 1
    Approved Symbol:
    TERF1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 14
    Human (de-) phosphorylation sites: 14; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02975 Entrez Gene ID: 7013 OMIM ID: 600951 Swissprot Accession: P54274;