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Description for Protein TEC

tec protein tyrosine kinase
32 total interacting proteins; 23 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/1)
(platelet: 1; undefined: 1)
Summary:
The protein encoded by this gene belongs to the Tec family of non-receptor protein-tyrosine kinases containing a pleckstrin homology domain. Tec family kinases are involved in the intracellular signaling mechanisms of cytokine receptors, lymphocyte surface antigens, heterotrimeric G-protein coupled receptors, and integrin molecules. They are also key players in the regulation of the immune functions. Tec kinase is an integral component of T cell signaling and has a distinct role in T cell activation. This gene may be associated with myelodysplastic syndrome. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • BTK: Bruton's tyrosine kinase Cys-rich motif
  • SH3: Src homology 3 domains
  • SH2: Src homology 2 domains
  • Tyr_Kinase: tyrosine kinase domain
  • PH: Pleckstrin homology domain.
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.10.2
    KEGG - Orthology:
    K07364
    KEGG - Pathway(s):
    hsa04660
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    PSCTK4
    Approved Symbol:
    TEC
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 4
    Human (de-) phosphorylation sites: 4; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 6
    Human phosphorylation targets: 5; Predicted platelet targets: 1
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02786 Entrez Gene ID: 7006 OMIM ID: 600583 Swissprot Accession: P42680;