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Description for Protein BUB1

budding uninhibited by benzimidazoles 1 homolog (yeast)
15 total interacting proteins; 7 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a kinase involved in spindle checkpoint function. The kinase functions in part by phosphorylating a member of the miotic checkpoint complex and activating the spindle checkpoint. Mutations in this gene have been associated with aneuploidy and several forms of cancer. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • S_T_kinase: Serine/Threonine protein kinases, catalytic domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.11.1
    KEGG - Orthology:
    K02178
    KEGG - Pathway(s):
    hsa04110; hsa04114; hsa04914
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Mitotic checkpoint serine/threonine protein kinase BUB1; BUB1A; BUB1L; Budding uninhibited by benzimidazoles 1 homolog
    Approved Symbol:
    BUB1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 25
    Human (de-) phosphorylation sites: 25; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 2
    Human phosphorylation targets: 2; Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Colorectal cancer with chromosomal instability(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03907 Entrez Gene ID: 699 OMIM ID: 602452 Swissprot Accession: O43683; Q53QE4;