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Description for Protein TCF20

transcription factor 20 (AR1)
6 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene binds a platelet-derived growth factor-responsive element in the matrix metalloproteinase 3 (stromelysin 1) promoter. The protein localizes to the nucleus and displays DNA-binding and transactivation activities. It is thought to be a transcriptional coactivator, enhancing the activity of transcription factors such as JUN and SP1. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • NLS: Nuclear localization signal
  • PHD: PHD zinc finger
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    None Available
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    KIAA0292; Transcription factor 20 isoform 2; SPRE-binding protein; Nuclear factor SPBP; AR1; SPBP; Stromelysin 1 PDGF-responsive element-binding protein; Stromelysin-1 platelet-derived growth factor-responsive element binding protein; Transcription factor 20 isoform 1
    Approved Symbol:
    TCF20
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 53
    Human (de-) phosphorylation sites: 53; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 04378 Entrez Gene ID: 6942 OMIM ID: 603107 Swissprot Accession: Q9UGU0;