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Description for Protein ZEB1

zinc finger E-box binding homeobox 1
9 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a zinc finger transcription factor. The encoded protein likely plays a role in transcriptional repression of interleukin 2. Mutations in this gene have been associated with posterior polymorphous corneal dystrophy-3 and late-onset Fuchs endothelial corneal dystrophy. Alternatively spliced transcript variants encoding different isoforms have been described. (PubMed Links)
Domains and Motifs:
  • CC: Coiled Coil
  • ZNFC2: zinc finger
  • HOX: Homeodomain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K09299
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    T-Lymphocyte specific interleukin 2 inhibitor Nil-2-a; NIL-2-A zinc finger protein negative regulator of IL2; Negative regulator of IL2; NIL-2-A zinc finger protein; AREB6; Nil-2-A; Zinc finger homeodomain enhancer binding; BZP; ZEB; ZEB1; ZFHEP; ZFHX1A
    Approved Symbol:
    ZEB1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 39
    Human (de-) phosphorylation sites: 39; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Corneal dystrophy, posterior polymorphous, 3(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01798 Entrez Gene ID: 6935 OMIM ID: 189909 Swissprot Accession: P37275; Q32Q63; B2RBI8;