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Description for Protein TCF7L2

transcription factor 7-like 2 (T-cell specific, HMG-box)
13 total interacting proteins; 9 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. The protein has been implicated in blood glucose homeostasis. Genetic variants of this gene are associated with increased risk of type 2 diabetes. Several transcript variants encoding multiple different isoforms have been found for this gene. (PubMed Links)
Domains and Motifs:
  • HMG: high mobility group
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04491
    KEGG - Pathway(s):
    hsa04310; hsa04520; hsa04916; hsa05200; hsa05210; hsa05213; hsa05215; hsa05216; hsa05217; hsa05221; hsa05412
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    TCF4; Transcription factor 7 like 2
    Approved Symbol:
    TCF7L2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 8
    Human (de-) phosphorylation sites: 8; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03751 Entrez Gene ID: 6934 OMIM ID: 602228 Swissprot Accession: Q9NQB0; Q6FHW4; C6ZRK5;