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Description for Protein TCEB1

transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)
27 total interacting proteins; 6 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(platelet: 1)
Summary:
This gene encodes the protein elongin C, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SKP1: Found in Skp1 protein family
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K03872
    KEGG - Pathway(s):
    hsa04120; hsa05200; hsa05211
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Transcription elongation factor B, polypeptide 1; S3 p15; Elongin C; EloC; Elongin 15 kDa subunit
    Approved Symbol:
    TCEB1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 2
    Human (de-) phosphorylation sites: 2; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02875 Entrez Gene ID: 6921 OMIM ID: 600788 Swissprot Accession: Q15369;