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Description for Protein TCEA2

transcription elongation factor A (SII), 2
32 total interacting proteins; 10 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene is found in the nucleus, where it functions as an SII class transcription elongation factor. Elongation factors in this class are responsible for releasing RNA polymerase II ternary complexes from transcriptional arrest at template-encoded arresting sites. The encoded protein has been shown to interact with general transcription factor IIB, a basal transcription factor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TFS2M: Domain in the central regions of transcription elongation factor S-II (and elsewhere)
  • ZnF_C2C2: C2C2 Zinc finger
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K03145
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    TFIIS; Transcription elongation factor A protein 2; Transcription elongation factor S-II protein 2; Testis-specific S-II; Transcription elongation factor TFIIS.l; Transcription elongation factor A protein 2 isoform a; Transcription elongation factor A protein 2 isoform b
    Approved Symbol:
    TCEA2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 11
    Human (de-) phosphorylation sites: 11; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 16069 Entrez Gene ID: 6919 OMIM ID: 604784 Swissprot Accession: Q86VL0; Q6IB64; Q15560;