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Description for Protein TBXAS1

thromboxane A synthase 1 (platelet)
No Interacting Proteins
Icon Book Platelet Evidence (proteome studies/others : 7/2)
(membrane: 2; microparticles: 1; platelet: 18; undefined: 2)
Summary:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to thromboxane A2, a potent vasoconstrictor and inducer of platelet aggregation. The enzyme plays a role in several pathophysiological processes including hemostasis, cardiovascular disease, and stroke. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    5.3.99.5
    KEGG - Orthology:
    K01832
    KEGG - Pathway(s):
    hsa00590; hsa01100
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Thromboxane A synthase 1; Thromboxane A synthase, Platelet; Cytochrome P450, subfamily V; CYP5; CYP5A1; Thromboxane synthatase; TXA synthase; TXS; Thromboxane A synthase 1 (platelet, cytochrome P450, family 5, subfamily A) isoform TXS-II; Thromboxane A synthase 1 (platelet, cytochrome P450, family 5, subfamily A) isoform TXS-I
    Approved Symbol:
    TBXAS1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Dazoxiben(db);
  • Ridogrel(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02035 Entrez Gene ID: 6916 OMIM ID: 274180 Swissprot Accession: Q53F23; P24557; B4DJG6;