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Description for Protein TBXA2R

thromboxane A2 receptor
17 total interacting proteins; 15 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/2)
(platelet: 4; undefined: 2)
Summary:
This gene encodes a member of the G protein-coupled receptor family. The protein interacts with thromboxane A2 to induce platelet aggregation and regulate hemostasis. A mutation in this gene results in a bleeding disorder. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04264
    KEGG - Pathway(s):
    hsa04020; hsa04080
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Thromboxane A2 receptor, platelet; Prostanoid TP receptor; TXA2-R; Thromboxane A2 receptor isoform 2; Thromboxane A2 receptor isoform 1
    Approved Symbol:
    TBXA2R
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 8
    Human (de-) phosphorylation sites: 8; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Ridogrel(db)

    Associated Genetic Diseases:

  • Bleeding disorder due to defective thromboxane A2 receptor(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 6
  • Isoform 1 : 6
    • Additional Identifiers:

    HPRD: 01768 Entrez Gene ID: 6915 OMIM ID: 188070 Swissprot Accession: Q0VAB0; P21731; Q05C92;