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Description for Protein SERPINA7

serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
1 total interacting proteins;
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
There are three proteins including thyroxine-binding globulin (TBG), transthyretin and albumin responsible for carrying the thyroid hormones thyroxine (T4) and 3,5,3 -triiodothyronine (T3) in the bloodstream. This gene encodes the major thyroid hormone transport protein, TBG, in serum. It belongs to the serpin family in genomics, but the protein has no inhibitory function like many other members of the serpin family. Mutations in this gene result in TGB deficiency, which has been classified as partial deficiency, complete deficiency, and excess, based on the level of serum TBG. Alternatively spliced transcript variants encoding different isoforms have been found, but the full-length nature of these variants has not been determined. (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • SERPIN: SERine Proteinase INhibitors
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    None Available
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Thyroxine binding globulin of serum; TBG; T4 binding globulin; TBG, serum; Serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
    Approved Symbol:
    SERPINA7
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Thyroxine-binding globulin deficiency, complete(Pd);
  • Thyroxine-binding globulin deficiency, complete, Buffalo type(Pd);
  • Thyroxine-binding globulin deficiency, complete, Jackson type(Pd);
  • Thyroxine-binding globulin deficiency, complete, Japanese type(Pd);
  • Thyroxine-binding globulin deficiency, complete, Kankakee type(Pd);
  • Thyroxine-binding globulin deficiency, complete, Negev type(Pd);
  • Thyroxine-binding globulin deficiency, partial, Gary type(Pd);
  • Thyroxine-binding globulin deficiency, partial, Japanese type(Pd);
  • Thyroxine-binding globulin deficiency, partial, Montreal type(Pd);
  • Thyroxine-binding globulin deficiency, partial, Quebec type(Pd);
  • Thyroxine-binding globulin Excess(Pd);
  • Thyroxine-binding globulin, Chicago(Pd);
  • Thyroxine-binding globulin, slow(Pd);
  • Thyroxine-binding globulin, variant A(Pd);
  • Thyroxine-binding globulin, variant P(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02438 Entrez Gene ID: 6906 OMIM ID: 314200 Swissprot Accession: P05543;