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Description for Protein TAT

tyrosine aminotransferase
3 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This nuclear gene encodes a mitochondrial protein tyrosine aminotransferase which is present in the liver and catalyzes the conversion of L-tyrosine into p-hydroxyphenylpyruvate. Mutations in this gene cause tyrosinemia (type II, Richner-Hanhart syndrome), a disorder accompanied by major skin and corneal lesions, with possible mental retardation. A regulator gene for tyrosine aminotransferase is X-linked. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
2.6.1.5
KEGG - Orthology:
K00815
KEGG - Pathway(s):
hsa00130; hsa00270; hsa00350; hsa00360; hsa00400; hsa01100
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
L-tyrosine:2-oxoglutarate aminotransferase
Approved Symbol:
TAT
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 1
Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • L-Glutamic Acid(db);
  • L-Phenylalanine(db);
  • L-Tyrosine(db);
  • Pyridoxal Phosphate(db)

    Associated Genetic Diseases:

  • Tyrosinemia, type II(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 11776 Entrez Gene ID: 6898 OMIM ID: 613018 Swissprot Accession: P17735;