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Description for Protein TAP2

transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
6 total interacting proteins; 5 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 2/0)
(membrane: 1; platelet: 15)
Summary:
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This gene is located 7 kb telomeric to gene family member ABCB2. The protein encoded by this gene is involved in antigen presentation. This protein forms a heterodimer with ABCB2 in order to transport peptides from the cytoplasm to the endoplasmic reticulum. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Alternative splicing of this gene produces two products which differ in peptide selectivity and level of restoration of surface expression of MHC class I molecules. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
  • AAA: ATPases associated with a variety of cellular activities
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K05654
    KEGG - Pathway(s):
    hsa02010; hsa04612; hsa05340
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Transporter, ATP binding cassette; Major histocompatibility complex, 2; ABC Transporter; MHC2; ATP binding cassette, subfamily B, member 3; ABCB3; ABC transporter, MHC 2; RING11; Peptide supply factor 2; PSF2; Peptide transporter PSF2; Antigen peptide transporter 2; APT2; Transporter 2, ATP binding cassette, sub family B isoform 1; Transporter 2, ATP binding cassette, sub family B isoform 2; Peptide transporter TAP2; Peptide transporter involved in antigen processing 2; Y1
    Approved Symbol:
    TAP2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 2
    Human (de-) phosphorylation sites: 2; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Bare lymphocyte syndrome, type I(Pd);
  • Peptide transporter PSF2 polymorphism(Pd);
  • Wegener-like granulomatosis(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 6
  • Isoform 1 : 6
    • Additional Identifiers:

    HPRD: 01360 Entrez Gene ID: 6891 OMIM ID: 170261 Swissprot Accession: Q03519; Q5HY71; Q9UP03;