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Description for Protein TAP1

transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
13 total interacting proteins; 9 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 2/1)
(membrane: 1; platelet: 9)
Summary:
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is involved in the pumping of degraded cytosolic peptides across the endoplasmic reticulum into the membrane-bound compartment where class I molecules assemble. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
  • AAA: ATPases associated with a variety of cellular activities
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K05653
    KEGG - Pathway(s):
    hsa02010; hsa04612; hsa05340
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    APT1; PSF1; ABC17; ABCB2; RING4; D6S114E; ABC transporter, MHC 1; Peptide supply factor 1; Antigen peptide transporter 1; ATP-binding cassette subfamily B, member 2; Transporter, ATP binding cassette major histocompatibility complex 1
    Approved Symbol:
    TAP1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Adenosine-5'-Diphosphate(db)

    Associated Genetic Diseases:

  • Bare lymphocyte syndrome, type I(Pd);
  • Peptide transporter PSF1 polymorphism(Pd);
  • TAP1 deficiency, somatic(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 7
    • Additional Identifiers:

    HPRD: 01359 Entrez Gene ID: 6890 OMIM ID: 170260 Swissprot Accession: Q03518;