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Description for Protein TAF11

TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa
23 total interacting proteins; 8 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a small subunit of TFIID that is present in all TFIID complexes and interacts with TBP. This subunit also interacts with another small subunit, TAF13, to form a heterodimer with a structure similar to the histone core structure. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • NLS: Nuclear localization signal
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K03135
    KEGG - Pathway(s):
    hsa03022
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Transcription initiation factor TFIID subunit 11; TBP associated factor 11; TFIID subunit p30 beta; Transcription initiation factor TFIID 28 kD subunit; TATA box binding protein associated factor 2I; TAF2I TBP associated factor RNA polymerase II 28 KD; PRO2134; MGC:15243; TAF2I; TATA box binding protein TBP associated factor RNA polymerase II I 28kD; TAFII28
    Approved Symbol:
    TAF11
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 3
    Human (de-) phosphorylation sites: 3; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 15980 Entrez Gene ID: 6882 OMIM ID: 600772 Swissprot Accession: Q15544;