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Description for Protein TAF6

TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
21 total interacting proteins; 4 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(platelet: 1)
Summary:
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the smaller subunits of TFIID that binds weakly to TBP but strongly to TAF1, the largest subunit of TFIID. Alternative splicing results in multiple transcript variants. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
None Available
KEGG - Orthology:
K03131
KEGG - Pathway(s):
hsa03022
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
TAF2E; TAFII70; TAFII80; TAFII85; Transcription initiation factor TFIID 70 kD subunit; TATA box binding protein associated factor 2E; TATA box binding protein (TBP) associated factor, RNA polymerase II, E, 70/85kD; TAF6 RNA polymerase II, TATA box binding protein (TBP) associated factor, 80kDa; MGC:8964; TBP-associated factor 6 isoform alpha; TBP-associated factor 6; TBP-associated factor 6 isoform gamma; TBP-associated factor 6 isoform delta
Approved Symbol:
TAF6
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 22
Human (de-) phosphorylation sites: 22; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

None Available

Associated Genetic Diseases:

None Available
Predicted Transmembrane Domains:
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 11807 Entrez Gene ID: 6878 OMIM ID: 602955 Swissprot Accession: P49848; A4D299;