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Description for Protein TAF4

TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa
26 total interacting proteins; 5 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the larger subunits of TFIID that has been shown to potentiate transcriptional activation by retinoic acid, thyroid hormone and vitamin D3 receptors. In addition, this subunit interacts with the transcription factor CREB, which has a glutamine-rich activation domain, and binds to other proteins containing glutamine-rich regions. Aberrant binding to this subunit by proteins with expanded polyglutamine regions has been suggested as one of the pathogenetic mechanisms underlying a group of neurodegenerative disorders referred to as polyglutamine diseases. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TAFH: TAF homology
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K03129
    KEGG - Pathway(s):
    hsa03022; hsa05016
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    TAF(II)135; Transcription initiation factor TFIID subunit 4; Transcription initiation factor TFIID 135 kDa subunit; TATA box binding protein (TBP) associated factor, RNA polymerase II, C1, 130kD; TAF4 RNA polymerase II, TATA box binding protein (TBP) associated factor, 135 kD; TAFII135; TAFII130; TAF2C; TAF2C1; TAF4A
    Approved Symbol:
    TAF4
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 3
    Human (de-) phosphorylation sites: 3; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 11797 Entrez Gene ID: 6874 OMIM ID: 601796 Swissprot Accession: O00268;