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Description for Protein TAF2

TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa
14 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the larger subunits of TFIID that is stably associated with the TFIID complex. It contributes to interactions at and downstream of the transcription initiation site, interactions that help determine transcription complex response to activators. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
None Available
KEGG - Orthology:
K03128
KEGG - Pathway(s):
hsa03022
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
TAF2 RNA polymerase II, TATA box binding protein (TBP) associated factor, 150kDa; TATA box binding protein associated factor 2B; TAF2B; TBP associated factor, RNA polymerase II, 150KD; TBP associated factor 2; Cofactor of initiator function 150KD subunit; CIF150; TATA box binding protein (TBP) associated factor, RNA polymerase II B, 150KD
Approved Symbol:
TAF2
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 7
Human (de-) phosphorylation sites: 7; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

None Available

Associated Genetic Diseases:

None Available
Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 07060 Entrez Gene ID: 6873 OMIM ID: 604912 Swissprot Accession: Q6P1X5; B3KMD8;