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Description for Protein TAF1

TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
48 total interacting proteins; 12 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is the basal transcription factor TFIID, which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes the largest subunit of TFIID. This subunit binds to core promoter sequences encompassing the transcription start site. It also binds to activators and other transcriptional regulators, and these interactions affect the rate of transcription initiation. This subunit contains two independent protein kinase domains at the N and C-terminals, but also possesses acetyltransferase activity and can act as a ubiquitin-activating/conjugating enzyme. This gene is part of a complex transcriptional unit (TAF1/DYT3), wherein some products share exons with TAF1 as well as additional exons downstream.[provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • CC: Coiled Coil
  • BROMO: bromo domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K03125
    KEGG - Pathway(s):
    hsa03022
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    TBP-associated factor 1 isoform 2; TATA box binding protein associated factor 2A; TAF2A; TBP-Associated factor, RNA polymerase II, 250 kD; TAFII250; Cell cycle, G1 phase defect; CCG1; Cell cycle gene1; Cell cycle block, G1-to-S; CCGS; BA2R; TFIID; TF2D; Tata-binding protein-containing complex; TBP-associated factor 250 kDa; P250; TBP-associated factor 1 isoform 1
    Approved Symbol:
    TAF1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 33
    Human (de-) phosphorylation sites: 33; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 2
    Human phosphorylation targets: 2; Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Dystonia-Parkinsonism, X-linked(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02436 Entrez Gene ID: 6872 OMIM ID: 313650 Swissprot Accession: P21675;