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Description for Protein TACR1

tachykinin receptor 1
5 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(undefined: 1)
Summary:
This gene belongs to a gene family of tachykinin receptors. These tachykinin receptors are characterized by interactions with G proteins and contain seven hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin substance P, also referred to as neurokinin 1. The encoded protein is also involved in the mediation of phosphatidylinositol metabolism of substance P. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04222
    KEGG - Pathway(s):
    hsa04020; hsa04080
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    NKIR; Tachykinin receptor 1 isoform long; Tachykinin receptor 1 isoform short; NK-1 receptor; NK-1R; TAC1R; NK1R; Neurokinin 1 receptor; Substance-P Receptor; SPR
    Approved Symbol:
    TACR1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Aprepitant(db);
  • Fosaprepitant(db);
  • Ketamine(db);
  • Vapreotide(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 7
  • Isoform 1 : 7
    • Additional Identifiers:

    HPRD: 01208 Entrez Gene ID: 6869 OMIM ID: 162323 Swissprot Accession: P25103;