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Description for Protein SVIL

supervillin
66 total interacting proteins; 38 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/1)
(phosphoproteome: 1; undefined: 1)
Summary:
This gene encodes a bipartite protein with distinct amino- and carboxy-terminal domains. The amino-terminus contains nuclear localization signals and the carboxy-terminus contains numerous consecutive sequences with extensive similarity to proteins in the gelsolin family of actin-binding proteins, which cap, nucleate, and/or sever actin filaments. The gene product is tightly associated with both actin filaments and plasma membranes, suggesting a role as a high-affinity link between the actin cytoskeleton and the membrane. The encoded protein appears to aid in both myosin II assembly during cell spreading and disassembly of focal adhesions. Two transcript variants encoding different isoforms of supervillin have been described. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • GEL: Gelsolin homology domain
  • VHP: Villin headpiece domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K10369
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Archvillin; Membrane-associated F-actin binding protein p205; Supervillin isoform 1; Supervillin isoform 2
    Approved Symbol:
    SVIL
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 71
    Human (de-) phosphorylation sites: 71; Platelet phosphorylation sites: 2
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 04992 Entrez Gene ID: 6840 OMIM ID: 604126 Swissprot Accession: O95425; Q569J5;